FGF-20 and DKK1 are transcriptional targets of b-catenin and FGF-20 is implicated in cancer and development
نویسندگان
چکیده
Mario N Chamorro, Donald R Schwartz, Alin Vonica, Ali H Brivanlou, Kathleen R Cho and Harold E Varmus* Cancer Biology and Genetics Program, Sloan-Kettering Institute, Varmus Laboratory, Memorial Sloan-Kettering Cancer Center, New York, NY, USA, Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI, USA, The Laboratory of Vertebrate Embryology, The Rockefeller University, New York, NY, USA and Cell Biology Program, Cornell University, Weill Graduate School of Medical Sciences, New York, NY, USA
منابع مشابه
FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development.
beta-catenin is the major effector of the canonical Wnt signaling pathway. Mutations in components of the pathway that stabilize beta-catenin result in augmented gene transcription and play a major role in many human cancers. We employed microarrays to identify transcriptional targets of deregulated beta-catenin in a human epithelial cell line (293) engineered to produce mutant beta-catenin and...
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تاریخ انتشار 2004